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Particle Metrix – Pharmacology, Drug Discovery and Delivery

Solubility of Proteins by Ionic Charge Monitoring

Protein molecules such as lysozymes, insulin or albumin have polyelectrolyte characteristics with ionic side groups. Therefore, understanding the pH dependence of protein solubility is a key factor in the formulation of stable protein solutions. pH dependent particle charge titrations and size distribution measurements were made with the particle charge analyzer Stabino® in a few minutes.

 

 

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