Flow Cytometry is an extremely effective tool for cell counting and molecular analysis but is usually limited to particles larger than ~400nm. Many emerging fields such as virology, microbiology, extra-cellular particles, and exosomes require higher sensitivity. The Apogee A60’s novel optical design allows detection of particles from 110nm thus making FACS analysis available for these disciplines. With up to 3 forward scatter detectors and 9 fluorescent channels, it is now possible to classify small particles at great speed and with robust statistics.