Pre-clinical Imaging

Overview
For many years in-vivo studies were conducted by sacrificing many lab animals at different time/disease points for longitudinal studies. In the past 2 decades, pre-clinical images have provided the possibility to track biological processes within the same animal over time, thus giving better insight and less variability in the studies. Today there are more in-vivo imaging modalities available for pre-clinical work than there are for clinical use, often with increased capabilities. Today pre-clinical imaging is the cornerstone of advanced and biomedical research and promotes transition to clinical studies and therapy.
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Use Cases
Pre-clinical imaging is often used to track pathologies over time. The most common uses are for tumor tracking and measurement/quantification, disease progression, therapeutic agent tracking for localization, biodistribution, and pharma-kinetics.
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Unique Benefits
Power your research with quality longitudinal data that is compatible with downstream clinical work.
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The Acuity Echo is the clinical, CE-Mark, MSOT (Multi-Spectral Optoacoustic Tomography). This system utilizes a unique handheld detector for the detection of optoacoustic signals emitted by laser excitation in the spectrum of 680-1300nm. Using a tunable laser, the MSOT acquires the acoustic signal emitted per wavelength excitation in a tomographic fashion. This allows the reconstruction of a 3D image that contains both anatomical and molecular information based on the absorbance spectrum of each material, such as tissue, oxygenated hemoglobin, deoxygenated hemoglobin, fat tissue, bone, near-infrared molecular markers (ICG), nanoparticles (GNR, GNP), and more. An image per wavelength is taken each 10th of a second enabling fast scanning of entire cross-sections for kinetics and biodistribution studies. For the anatomical image, a novel 3D ultrasound tomography is used to give an incredibly sharp image.
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Mediso is world leading manufacturer of clinical and pre-clinical multi modal in-vivo imaging systems that combine nuclear imaging together with MRI (3T,7T) and CT. The Nanoscan product line is leading the world of pre-clinical research with best in class resolution and sensitivity.
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Fluorescence and bioluminescence is the most common method of pre-clinical in-vivo imaging. By using fluorescent or bioluminescent reporter genes it is possible to track gene expression, tissue growth, response to therapy, and much more applications.
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Ultrasound works by transmitting ultrasound waves and detecting the waves that bounce back from structures live images of soft tissue, vasculature, and organs are reconstructed. By using the doppler effect it is possible to measure to direction and speed of blood flow in blood vessels and the heart. Ultrasound is preferred for many applications due to its quick, real-time imaging with no required contrast agents or radiation. The pre-clinical ultrasound systems utilize high frequency to resolve small structures in rodents, including 6.5 days-old embryos.
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RSOM – Raster Scan Optoacoutic Mesoscopy is a technology utilizing optoacoustics for imaging vascular microenvironment at an extremely high resolution of 10um. Optoacoutics excels at imaging hemoglobin as it is the main natural 532nm light absorber in living tissue. By exciting subcutaneous tissue with a 532nm laser, and detecting the ultrasound signal emitted, by a raster moving ultrasound detector, an image of small and large blood vessels is reconstructed and analyzed.
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The MSOT inVision system from iThera-Medical stands out as a revolutionary pre-clinical imaging platform, offering unparalleled capabilities for researchers studying small animal models. It leverages the groundbreaking technology of Multispectral Optoacoustic Tomography (MSOT) to deliver real-time, high-resolution anatomical imaging with exceptional soft tissue contrast, combined with the power of molecular imaging. This unique combination provides researchers with a comprehensive view of biological processes in living animals, accelerating discoveries in various fields.

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