Pre-clinical Imaging

Overview

For many years in-vivo studies were conducted by sacrificing many lab animals at different time/disease points for longitudinal studies. In the past 2 decades, pre-clinical images have provided the possibility to track biological processes within the same animal over time, thus giving better insight and less variability in the studies. Today there are more in-vivo imaging modalities available for pre-clinical work than there are for clinical use, often with increased capabilities. Today pre-clinical imaging is the cornerstone of advanced and biomedical research and promotes transition to clinical studies and therapy.

Use Cases

Pre-clinical imaging is often used to track pathologies over time. The most common uses are for tumor tracking and measurement/quantification, disease progression, therapeutic agent tracking for localization, biodistribution, and pharma-kinetics.

Unique Benefits

Power your research with quality longitudinal data that is compatible with downstream clinical work.

The KUBTEC PARAMETER® line is the company's cabinet X-ray platform for the research laboratory, running from straightforward high-resolution radiography up to multislice tomosynthesis. Across the line, Image Blender™ overlays the X-ray onto an optical photograph of the same specimen so the signal is read against real anatomy, and DIGIMUS Multi turns scans into quantitative bone mineral density and whole-body composition figures aligned with DXA methodology. Merkel Technologies supplies the complete PARAMETER range in Israel.

The KUBTEC XPERT® 80 line is the company's high-resolution cabinet X-ray platform, sitting alongside the PARAMETER systems and sharing their sub-50 µm resolution and DIGICOM specimen radiography software. Two models make up the line: the XPERT® 80 and the sharper XPERT® 80-L. Merkel Technologies supplies both in Israel.

Mediso is world leading manufacturer of clinical and pre-clinical multi modal in-vivo imaging systems that combine nuclear imaging together with MRI (3T,7T) and CT. The Nanoscan product line is leading the world of pre-clinical research with best in class resolution and sensitivity.

Fluorescence and bioluminescence is the most common method of pre-clinical in-vivo imaging. By using fluorescent or bioluminescent reporter genes it is possible to track gene expression, tissue growth, response to therapy, and much more applications.

Ultrasound works by transmitting ultrasound waves and detecting the waves that bounce back from structures live images of soft tissue, vasculature, and organs are reconstructed. By using the doppler effect it is possible to measure to direction and speed of blood flow in blood vessels and the heart. Ultrasound is preferred for many applications due to its quick, real-time imaging with no required contrast agents or radiation. The pre-clinical ultrasound systems utilize high frequency to resolve small structures in rodents, including 6.5 days-old embryos.

Pre-clinical Imaging

KUBTEC PARAMETER® X-ray Imaging Systems

KUBTEC XPERT® 80 X-ray Imaging Systems

Mediso nanoScan PET/MRI

Spectral Instruments Imaging — In Vivo Fluorescence and Bioluminescence

S-Sharp Prospect T1 Preclinical Ultrasound Imaging