We're Here To Help

Please fill out our form,and we’ll get in touch shortly.

    Biomarkers

    Biomarkers, coined from an almagm of biological and marker, refer to a vast range of chemicals and physiological phenomena. Defined by the NIH as “a characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention.” it can be used for diagnosis, prognosis, or even as a screening tool for population research. A biomarker can therefore be a protein or peptide… but also a nucleic acid, lipid, carbohydrate – or a modified form of all of the above.

    Prostate specific antigen, for example, can be used as a biomarker for prostate cancer and is considered to be very useful for prognosis. Biomarkers can be detected via ELISA, FACS, positron emission tomography, diffusion magnetic resonance and a variety of other methods.

    The vast increase in computaittional power and advances in analytical technologies such as gas chromatography and mass spectronomy have empowered the search for biomarkers tremeandously over the past decades, helping researchers find the proverbial needle in the haystack. The difficulty arises from the challenge of identifying something which is expressed only slightly variantly under abnormal conditions.

    For a newly discovered biomarker to be accepted as a legitimate and useful it needs to be validated as an assay capable of separating the abnormal condition from the normal range of the population – the reference range that is true for 95% of the population. The accepted gold standard requires validation versus a population of at least 200 subjects. Needless to say, considerable fiddling with the assay can be expected before it is tested on such a large study population.

    whether you are in the process of perfecting your own assay, and are looking into various alternate techniques, or are seeking a validated assay for an epidemiological study, contact Merkel today for a range of options, as well as advice and technical support in selecting the optimal option for you.

    We're Here To Help

    Please fill out our form,and we’ll get in touch shortly.

      Discuss your R&D challenges with us - No obligation, no cost!

      We have been providing researchers, companies and academic institutes with advanced solutions for characterization, imaging and sorting of nanoparticle, bacteria, virus, cell, algae and other particles - as well as imaging of plants, mice and rats in a variety of imaging modalities. Our global network of application specialists empower us to provide you with the most recent and effective technologies and protocols for obtaining the answers to your most pressing research questions. Contact us to discuss your needs. No cost and no obligation for a first consultation. We are accustomed to working with start up companies and will consider signing an NDA if needed.

      Leading technology. Expert application and technical support.

      We understand that you have no time for experimentation - when it comes to the instruments that you need for your research work. We supply top quality instruments together with friendly and all-encompassing operator training. Add expert technical and application support - and you are ready to go!