Neurofilament Light Chain
What is Neurofilament light (NfL)? It is essentially no more than a 68kDa cytoskeletal intermediate filament expressed in neurons. Together with the 200 kDa neurofilament heavy (NfH) and the 125 kDa neurofilament medium (NfM) it forms neurofilaments. Neurofilaments are the backbone of the neuronal cytoskeleton. Their phosphorylation/dephosphorylation regulates the expansion/ contraction of the microtubules.
What is Neurodegenerative disease?
The research and biomedical utility of NF-light stems from the fact that it is released in significant, and detectable, quantities following neuronal damage and degeneration. Neurofilament light is accordingly elevated in neurodegenerative disorders associated with the destruction of white matter. It can be used as a biomarker for traumatic brain injury, multiple sclerosis, dementia and other neurological and neurodegenerative illnesses. Indeed, it is not just a validated biomarker for neurological diseases, its levels have been found to rise, in humans, with age. Its levels have also been found to be in correlation with various other neural pathway-associated proteins. In the elderly, plasma NfL levels reveal a higher correlation to mortality than conventional measures used to asses cognitive or physical function. Plasma NfL levels also increase in mice with age, whereas dietary restriction, a treatment found to increase lifespan in mice, ameliorates plasma NfL level increase associated with age.
Merkel will be happy to provide you with a variety of associated molecules and to offer technical advice regarding their deployment.
What is neurodegenerative disease?
The brain is an extremely complex organ with many pathways that allow us to do the amazing things we do. Since the brain is complex, brain diseases can be caused by poor communication between cells. Neurodegenerative diseases can cause the death of nerve cells. The word neurodegenerative is made up of two words: neuro meaning brain, and degenerative meaning degeneration. Neurodegenerative diseases are a good example of the severe effects that poor communication between nerve cells can have.
Neurodegenerative disease-Parkinson’s disease
Parkinson’s disease is a neurodegenerative disease whose main symptoms are related to movement problems due to the death of nerve cells of the brain. It is one type of neurodegenerative disease. When neurons die in a certain area of the brain, an area of the brain that communicates and allows us to move, movement problems appear.
Neurodegenerative disease-Huntington’s disease
Similar to Parkinson’s disease, Huntington’s disease is a neurodegenerative disease that can be passed from parent to child and affects the basal ganglia in a way that creates movement difficulties. It is also a neurodegenerative disease that causes difficulties in movement and affects the basal ganglia. Unlike Parkinson’s disease, Huntington’s disease is a hereditary disease, a disease that can be inherited. This means that if one of the parents is sick with an old disease, there is a high probability that the children will also get it. Huntington’s disease results from an abnormal accumulation of protein in the brain, which causes the death of nerve cells. This death in turn causes mobility impairments. Mostly, people who are sick with this disease will exhibit excess mobility that is often unwanted or unnecessary. For example, they will often experience constant tremors in their limbs, which is out of their control. As the disease progresses, people with Huntington’s disease have more difficulty moving the way they want.