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MSOT - Multi-Spectral Optoacoustic Tomography

Overview

The MSOT inVision system from iThera-Medical stands out as a revolutionary pre-clinical imaging platform, offering unparalleled capabilities for researchers studying small animal models. It leverages the groundbreaking technology of Multispectral Optoacoustic Tomography (MSOT) to deliver real-time, high-resolution anatomical imaging with exceptional soft tissue contrast, combined with the power of molecular imaging. This unique combination provides researchers with a comprehensive view of biological processes in living animals, accelerating discoveries in various fields.

Use Cases

Oncology Research: MSOT's ability to visualize tumor growth, monitor blood flow, and detect hypoxia (low oxygen levels) within tumors makes it valuable for cancer research. Researchers can study tumor progression, evaluate treatment efficacy, and potentially develop new anti-cancer therapies.
Angiogenesis and Vascularization: The system excels at imaging blood vessels, allowing researchers to study angiogenesis (new blood vessel formation) in various contexts, such as wound healing, tumor development, and cardiovascular disease models.
Inflammation and Infection Research: By visualizing inflammatory processes and monitoring immune cell activity, MSOT inVision aids researchers in understanding inflammatory diseases and developing new treatment strategies.
Drug Delivery Studies: Researchers can utilize MSOT to track the delivery and biodistribution of therapeutic agents within the animal model, allowing for the optimization of drug delivery systems.
Neuroscience Research: The ability to monitor blood flow and oxygenation in the brain makes MSOT valuable for studying neurological disorders, stroke models, and brain development.

Unique Benefits

Real-Time Visualization: Unlike traditional techniques that require sacrificing animals for analysis, MSOT inVision offers real-time imaging capabilities. This allows researchers to observe dynamic biological processes, track changes within living animals, and potentially reduce the number of animals needed for studies.
Exceptional Soft Tissue Imaging: MSOT utilizes tomographic ultrasound technology, providing detailed anatomical images with superior soft tissue contrast compared to traditional X-ray or CT scans. This allows for clear visualization of organs, blood vessels, and other soft tissue structures within the animal model.
Molecular Imaging Power: The optoacoustic properties of MSOT enable molecular imaging. By employing near-infrared light, the system can detect and differentiate endogenous chromophores like oxygenated and deoxygenated hemoglobin. Additionally, researchers can leverage exogenic molecular markers, such as infrared probes or nanoparticles, to target specific cells or processes within the animal.
High-Resolution and Deep Tissue Penetration: MSOT inVision offers high-resolution images, allowing researchers to visualize fine details within the animal subject. The system also boasts impressive deep tissue penetration capabilities, enabling the study of biological processes throughout the entire small animal body.
Non-invasive and Label-Free (Endogenous Markers): MSOT imaging is non-invasive, minimizing stress on the animal model. Furthermore, the ability to detect endogenous markers eliminates the need for complex labeling procedures, preserving the integrity of the animal and offering a more natural representation of biological processes.

Resources

MSOT - Multi-Spectral Optoacoustic Tomography

MSOT - Multi-Spectral Optoacoustic Tomography

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