ZetaView

Overview

The Zetaview system utilizes Nanoparticle Tracking Analysis (NTA) technology for the characterization of nanoparticles in suspension. NTA tracks the Brownian motion of individual nanoparticles under a laser light source. By analyzing their movement patterns, the system determines the hydrodynamic size and size distribution (polydispersity) of the particles. Additionally, some Zetaview models can measure the zeta potential, a crucial parameter reflecting the surface charge of a particle. The NTA method provides a rapid and non-invasive approach for characterizing nanoparticles in various applications, including disease biomarker detection, protein research, and drug delivery.

Use Cases

Disease Biomarker Detection: Zetaview, coupled with specific fluorescent probes, can be used for the rapid and sensitive detection of disease-related exosomes in patient samples. By analyzing the size, surface markers, and co-localization patterns of exosomes, researchers can potentially develop novel diagnostic tools for various diseases.
Exosome Characterization: The system allows researchers to characterize the size distribution, surface charge, and heterogeneity of exosomes isolated from biological fluids. This information is crucial for understanding the role of exosomes in various physiological and pathological processes.
Liquid Biopsy Analysis: Zetaview can be used to analyze exosomes isolated from minimally invasive liquid biopsies, such as blood or urine. This approach offers a promising alternative to traditional tissue biopsies for disease diagnosis and monitoring.

Unique Benefits

Rapid measurement: The Zetaview system provides fast and reliable results within minutes, accelerating nanoparticle characterization workflows.
Multiplexed Fluorescence Detection: Advanced Zetaview models boast multi-laser excitation capabilities, enabling the use of up to four different fluorescent probes simultaneously. This allows researchers to interrogate exosomes for specific surface markers associated with various diseases. By analyzing the fluorescence intensity associated with each exosome, researchers can identify subpopulations containing disease-related biomarkers within a complex biological sample.
Co-localization Analysis: The latest Zetaview models offer innovative co-localization features for exosome classification based on two fluorescent labels. This functionality is particularly valuable for studying the heterogeneity of exosome populations. By analyzing co-localization patterns, researchers can differentiate subpopulations expressing specific combinations of disease markers, providing deeper insights into potential diagnostic applications.
High Sensitivity: The system can detect individual exosomes, which are typically within the range of 30-150 nm in diameter.
Ease of use: The system features an intuitive interface and automated analysis, making it accessible to researchers with varying levels of experience.

Resources

ZetaView

ZetaView

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