We're Here To Help

Please fill out our form,and we’ll get in touch shortly.


    Exosomes are small membrane vesicles (30–150 nm) of endocytic origin, All cells secret them constantly under both healthy and pathological conditions and they can be found in various body fluids including blood, saliva, urine, semen, bile, ascites, and gastrointestinal lavage fluid. Exosomes can contain proteins, nucleic acids (DNA fragments as well as microRNAs, long-noncoding RNAs, intact and mutated mRNAs), lipids and various other metabolites (amino acids, sugars, etc.)

    Exosomes are a central mechanism of cell signaling (autocrine, paracrine, endocrine and juxtracrine), and have recently been found to play a central role in cancer progression, angiogenesis, immune suppression and metastasis. Furthermore, they have been found to contain many potential disease specific biomarkers, as well as treatment prognosis. Other research efforts have sought to exploit the natural biomolecule carrier trait of exosomes for drug delivery purposes.

    It is no wonder that many labs are seeking optimal exosome isolation methods to secure the best yield, reproducibility and purity. The classical ultracentrifugation method can now be supplemented or exchanged by commercial kits based on various principles including:

    • charge neutralization-based precipitation
    • gel-filtration
    • affinity purification using magnetic beads

    Confusingly, no single method appears to be universally superior in every parameter, with differences in yield, purity and integrity of the isolated exosomes lending different methods and kits to different applications.

    Are you deliberating which exosome purification assay will best suit your needs? Or are you looking for a reliable exosome biomarker assay? Either way, contact Merkel today. Not only will we present you with all of our options, we will also be able to save you valuable time by advising you on the option best suited for the unique needs (and budget…) of your lab, giving you the extra edge you need to outscoop the competition!

    We're Here To Help

    Please fill out our form,and we’ll get in touch shortly.

      Discuss your R&D challenges with us - No obligation, no cost!

      We have been providing researchers, companies and academic institutes with advanced solutions for characterization, imaging and sorting of nanoparticle, bacteria, virus, cell, algae and other particles - as well as imaging of plants, mice and rats in a variety of imaging modalities. Our global network of application specialists empower us to provide you with the most recent and effective technologies and protocols for obtaining the answers to your most pressing research questions. Contact us to discuss your needs. No cost and no obligation for a first consultation. We are accustomed to working with start up companies and will consider signing an NDA if needed.

      Leading technology. Expert application and technical support.

      We understand that you have no time for experimentation - when it comes to the instruments that you need for your research work. We supply top quality instruments together with friendly and all-encompassing operator training. Add expert technical and application support - and you are ready to go!