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    NF light

    What is Neurofilament light (NfL)? It is essentially no more than a 68kDa cytoskeletal intermediate filament expressed in neurons. Together with the 200 kDa neurofilament heavy (NfH) and the 125 kDa neurofilament medium (NfM) it forms neurofilaments. Neurofilaments are the backbone of the neuronal cytoskeleton. Their  phosphorylation/dephosphorylation regulates the expansion/ contraction of the microtubules.

    The research and biomedical utility of NF-light stems from the fact that it is released in significant, and detectable, quantities following neuronal damage and degeneration. Neurofilament light accordingly elevated in neurodegenerative disorders associated with the destruction of white matter and can be used as a biomarker for traumatic brain injury, multiple sclerosis, dementia and other neurological and neurodegenerative illnesses. Indeed, it is not just a validated biomarker for neurological diseases, its levels have been found to rise, in humans, with age. Its levels have also been found to be in correlation with  various other neural pathway sassoicated proteins. In the elderly, plasma NfL levels reveal a higher correlation to mortality than conventional measures used to asses cognitive or physical function. Plasma NfL levels also increase in mice with age, whereas dietary restriction, a treatment found to increase lifespan in mice, ameliorates plasma NfL level increase associated with age.

    Merkel will be happy to provide you with a variety of associated molecules, and to offer technical advice regarding their deployment.

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